Temporal transcriptome changes induced by MDV in Marek's disease-resistant and -susceptible inbred chickens.

ABSTRACT:

Background

Marek's disease (MD) is a lymphoproliferative disease in chickens caused by Marek's disease virus (MDV) and characterized by T cell lymphoma and infiltration of lymphoid cells into various organs such as liver, spleen, peripheral nerves and muscle. Resistance to MD and disease risk have long been thought to be influenced both by genetic and environmental factors, the combination of which contributes to the observed outcome in an individual. We hypothesize that after MDV infection, genes related to MD-resistance or -susceptibility may exhibit different trends in transcriptional activity in chicken lines having a varying degree of resistance to MD.

Results

In order to study the mechanisms of resistance and susceptibility to MD, we performed genome-wide temporal expr

SUBMITTER: Yu Y 

PROVIDER: S-EPMC3269463 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature