Resting cerebral metabolism correlates with skin conductance and functional brain activation during fear conditioning.

ABSTRACT: We investigated whether resting brain metabolism can be used to predict autonomic and neuronal responses during fear conditioning in 20 healthy humans. Regional cerebral metabolic rate for glucose was measured via positron emission tomography at rest. During conditioning, autonomic responses were measured via skin conductance, and blood oxygen level dependent signal was measured via functional magnetic resonance imaging. Resting dorsal anterior cingulate metabolism positively predicted differentially conditioned skin conductance responses. Midbrain and insula resting metabolism negatively predicted midbrain and insula functional reactivity, while dorsal anterior cingulate resting metabolism positively predicted midbrain functional reactivity. We conclude that resting metabolism in limbic a

SUBMITTER: Linnman C 

PROVIDER: S-EPMC3269527 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature