Evaluation of multiple risk-associated single nucleotide polymorphisms versus prostate-specific antigen at baseline to predict prostate cancer in unscreened men.

ABSTRACT:

Background

Although case-control studies have identified numerous single nucleotide polymorphisms (SNPs) associated with prostate cancer, the clinical role of these SNPs remains unclear.

Objective

Evaluate previously identified SNPs for association with prostate cancer and accuracy in predicting prostate cancer in a large prospective population-based cohort of unscreened men.

Design, setting, and participants

This study used a nested case-control design based on the Malmö Diet and Cancer cohort with 943 men diagnosed with prostate cancer and 2829 matched controls. Blood samples were collected between 1991 and 1996, and follow-up lasted through 2005.

Measurements

We genotyped 50 SNPs, analyzed prostate-specific antigen (PSA) in blood from baseline, and tested fo

SUBMITTER: Klein RJ 

PROVIDER: S-EPMC3269546 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature