Binary fluorous tagging enables the synthesis and separation of a 16-stereoisomer library of macrosphelides.

ABSTRACT: Fluorous mixture synthesis minimizes the effort to synthesize small-molecule libraries by labelling the molecules rather than the reaction vessels. Reactants are labelled with fluorinated tags and products can later be demixed based on the fluorine content. A limit in the number of available tags can be overcome by using binary encoding so that a total of four tags can label uniquely a library of 16 compounds. This strategy, however, means that separation based on fluorine content alone is not possible. Here, we solve this problem by selectively removing one tag after an initial demixing step; a second demixing provides each individual compound. The usefulness of this strategy is demonstrated by the synthesis of a library that contains all 16 diastereomers of the natural products macrosphe

SUBMITTER: Curran DP 

PROVIDER: S-EPMC3269761 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature