Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes.

ABSTRACT:

Background

An impaired glomerular filtration rate (GFR) leads to end-stage renal disease and increases the risks of cardiovascular disease and death. Persons with type 1 diabetes are at high risk for kidney disease, but there are no interventions that have been proved to prevent impairment of the GFR in this population.

Methods

In the Diabetes Control and Complications Trial (DCCT), 1441 persons with type 1 diabetes were randomly assigned to 6.5 years of intensive diabetes therapy aimed at achieving near-normal glucose concentrations or to conventional diabetes therapy aimed at preventing hyperglycemic symptoms. Subsequently, 1375 participants were followed in the observational Epidemiology of Diabetes Interventions and Complications (EDIC) study. Serum creatinine levels wer

SUBMITTER: DCCT/EDIC Research Group 

PROVIDER: S-EPMC3270008 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature