Genetic polymorphisms in obesity-related genes and endometrial cancer risk.

ABSTRACT:

Background

Obesity is associated with circulating levels of adiponectin and leptin and endometrial cancer risk. Little is known about whether single nucleotide polymorphisms (SNPs) in the genes that encode adiponectin (ADIPOQ), leptin (LEP), adiponectin receptor 1 (ADIPOR1), adiponectin receptor 2 (ADIPOR2), and leptin receptor (LEPR) are associated with endometrial cancer.

Methods

The authors selected 87 tagging SNPs to capture common genetic variants in these 5 genes. These SNPs were evaluated in 1028 endometrial cancer cases and 1932 community controls recruited from Chinese women. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs).

Results

Three of the 10 SNPs evaluated in the ADIPOQ gene were significantly as

SUBMITTER: Chen X 

PROVIDER: S-EPMC3270123 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature