Plasmid-Mediated Quinolone Resistance; Interactions between Human, Animal, and Environmental Ecologies.

ABSTRACT: Resistance to quinolones and fluoroquinolones is being increasingly reported among human but also veterinary isolates during the last two to three decades, very likely as a consequence of the large clinical usage of those antibiotics. Even if the principle mechanisms of resistance to quinolones are chromosome-encoded, due to modifications of molecular targets (DNA gyrase and topoisomerase IV), decreased outer-membrane permeability (porin defect), and overexpression of naturally occurring efflux, the emergence of plasmid-mediated quinolone resistance (PMQR) has been reported since 1998. Although these PMQR determinants confer low-level resistance to quinolones and/or fluoroquinolones, they are a favorable background for selection of additional chromosome-encoded quinolone resistance mechani

SUBMITTER: Poirel L 

PROVIDER: S-EPMC3270319 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature