Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.

ABSTRACT: Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis. CD is characterized as a chronic inflammatory disease of the gastrointestinal tract, ranging from the mouth to the anus. Although there are gross pathological and histological similarities between CD and Johne's disease of cattle, the cause of CD remains controversial. It is vital to understand fully the cause of this disease because it affects approximately 500,000 people in North America and Europe. It ranges from 27 to 48 cases per 100,000 people. There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients. Regardless of the environmental trigger, there

SUBMITTER: Naser SA 

PROVIDER: S-EPMC3270503 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature