Brain volume reductions within multiple cognitive systems in male preterm children at age twelve.

ABSTRACT:

Objectives

To more precisely examine regional and subregional microstructural brain changes associated with preterm birth.

Study design

We obtained brain volumes from 29 preterm children, age 12 years, with no ultrasound scanning evidence of intraventricular hemorrhage or cystic periventricular leukomalacia in the newborn period, and 22 age- and sex-matched term control subjects.

Results

Preterm male subjects demonstrated significantly lower white matter volumes in bilateral cingulum, corpus callosum, corticospinal tract, prefrontal cortex, superior and inferior longitudinal fasciculi compared with term male subjects. Gray matter volumes in prefrontal cortex, basal ganglia, and temporal lobe also were significantly reduced in preterm male subjects. Brain volumes of pr

SUBMITTER: Kesler SR 

PROVIDER: S-EPMC3270939 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature