Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.

ABSTRACT: Lahn and Page previously observed that genes on the human X chromosome were physically arranged along the chromosome in "strata," roughly ordered by degree of divergence from related genes on the Y chromosome. They hypothesized that this ordering results from a historical series of suppressions of recombination along the mammalian Y chromosome, thereby allowing formerly recombining X and Y chromosomal genes to diverge independently. Here predictions of this hypothesis are confirmed in a nonprimate mammalian order, Rodentia, through an analysis of eight gene pairs from the X and Y chromosomes of the house mouse, Mus musculus. The mouse X chromosome has been rearranged relative to the human X, so strata were not found in the same physical order on the mouse X. However, based on synonymous ev

SUBMITTER: Sandstedt SA 

PROVIDER: S-EPMC327101 | biostudies-literature | 2004 Feb

REPOSITORIES: biostudies-literature