Project description:<p>Malaria varies in severity, with complications ranging from uncomplicated to severe malaria. Severe malaria could be attributed to peripheral hyperparasitemia or cerebral malaria. The metabolic interactions between the host and <em>Plasmodium</em> species are yet to be understood during these infections of varied pathology and severity. An untargeted metabolomics approach utilizing the liquid chromatography-mass spectrometry platform has been used to identify the affected host metabolic pathways and associated metabolites in the serum of murine malaria models with uncomplicated malaria, hyperparasitemia and experimental cerebral malaria. We report that mice with malaria share similar metabolic attributes like higher levels of bile acids, bile pigments, and steroid hormones that have been reported for human malaria infections. Moreover, in severe malaria, upregulated levels of metabolites like phenylalanine, histidine, valine, pipecolate, ornithine and pantothenate, with decreased levels of arginine and hippurate, were observed. Metabolites of sphingolipid metabolism were upregulated in experimental cerebral malaria. Higher levels of 20-hydroxy-leukotriene B4 and epoxyoctadecamonoenoic acids were found in uncomplicated malaria, with lower levels observed for experimental cerebral malaria. Our study provides insights into host biology during different pathological stages of malaria disease and would be useful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria.</p>

2022-09-14 | MTBLS4387 | MetaboLights

Annexin Animal Models-From Fundamental Principles to Translational Research.

Project description: Not available

| S-EPMC8037771 | biostudies-literature

Do we still need animals? Surveying the role of animal-free models in Alzheimer's and Parkinson's disease research.

Project description: Not available

| S-EPMC8922267 | biostudies-literature

Dystrophin-deficient large animal models: translational research and exon skipping.

Project description: Not available

| S-EPMC4568789 | biostudies-literature

Natural non-trasgenic animal models for research in Alzheimer's disease.

Project description: Not available