Defining the boundaries of normal thrombin generation: investigations into hemostasis.

ABSTRACT: In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of more dramatic composition differences are studied. In this study we have defined the consequences of normal range variation of components of the coagulation proteome by using a mechanism-based computational approach that translates coagulation factor concentration data into a representation of an individual's thrombin generation potential. A novel graphical method is used to integrate standard measures that characterize thrombin generation in both empirical and computational models (e.g max rate, max level, total thrombin, time to 2 nM thr

SUBMITTER: Danforth CM 

PROVIDER: S-EPMC3271084 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature