Common genetic variants in sex hormone pathway genes and papillary thyroid cancer risk.

ABSTRACT:

Background

Hormonal differences are hypothesized to contribute to the approximately ≥2-fold higher thyroid cancer incidence rates among women compared with men worldwide. Although thyroid cancer cells express estrogen receptors and estrogen has a proliferative effect on papillary thyroid cancer (PTC) cells in vitro, epidemiologic studies have not found clear associations between thyroid cancer and female hormonal factors. We hypothesized that polymorphic variation in hormone pathway genes is associated with the risk of developing papillary thyroid cancer.

Methods

We evaluated the association between PTC and 1151 tag single nucleotide polymorphisms (SNPs) in 58 candidate gene regions involved in sex hormone synthesis and metabolism, gonadotropins, and prolactin in a case-cont

SUBMITTER: Schonfeld SJ 

PROVIDER: S-EPMC3271376 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature