Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function.

ABSTRACT: Enteroviral infection can lead to dilated cardiomyopathy (DCM), which is a major cause of cardiovascular mortality worldwide. However, the pathogenetic mechanisms have not been fully elucidated. Serum response factor (SRF) is a cardiac-enriched transcription regulator controlling the expression of a variety of target genes, including those involved in the contractile apparatus and immediate early response, as well as microRNAs that silence the expression of cardiac regulatory factors. Knockout of SRF in the heart results in downregulation of cardiac contractile gene expression and development of DCM. The goal of this study is to understand the role of SRF in enterovirus-induced cardiac dysfunction and progression to DCM. Here we report that SRF is cleaved following enteroviral infection of

SUBMITTER: Wong J 

PROVIDER: S-EPMC3271589 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature