New insights regarding HCV-NS5A structure/function and indication of genotypic differences.

ABSTRACT:

Background

HCV is prevalent throughout the world. It is a major cause of chronic liver disease. There is no effective vaccine and the most common therapy, based on Peginterferon, has a success rate of ~50%. The mechanisms underlying viral resistance have not been elucidated but it has been suggested that both host and virus contribute to therapy outcome. Non-structural 5A (NS5A) protein, a critical virus component, is involved in cellular and viral processes.

Methods

The present study analyzed structural and functional features of 345 sequences of HCV-NS5A genotypes 1 or 3, using in silico tools.

Results

There was residue type composition and secondary structure differences between the genotypes. In addition, second structural variance were statistical different for e

SUBMITTER: Yamasaki LH 

PROVIDER: S-EPMC3271958 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature