Microtubules are organized independently of the centrosome in Drosophila neurons.

ABSTRACT:

Background

The best-studied arrangement of microtubules is that organized by the centrosome, a cloud of microtubule nucleating and anchoring proteins is clustered around centrioles. However, noncentrosomal microtubule arrays are common in many differentiated cells, including neurons. Although microtubules are not anchored at neuronal centrosomes, it remains unclear whether the centrosome plays a role in organizing neuronal microtubules. We use Drosophila as a model system to determine whether centrosomal microtubule nucleation is important in mature neurons.

Results

In developing and mature neurons, centrioles were not surrounded by the core nucleation protein γ-tubulin. This suggests that the centrioles do not organize functional centrosomes in Drosophila neurons in vivo. C

SUBMITTER: Nguyen MM 

PROVIDER: S-EPMC3271965 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature