Association of HADHA expression with the risk of breast cancer: targeted subset analysis and meta-analysis of microarray data.

ABSTRACT:

Background

The role of n-3 fatty acids in prevention of breast cancer is well recognized, but the underlying molecular mechanisms are still unclear. In view of the growing need for early detection of breast cancer, Graham et al. (2010) studied the microarray gene expression in histologically normal epithelium of subjects with or without breast cancer. We conducted a secondary analysis of this dataset with a focus on the genes (n = 47) involved in fat and lipid metabolism. We used stepwise multivariate logistic regression analyses, volcano plots and false discovery rates for association analyses. We also conducted meta-analyses of other microarray studies using random effects models for three outcomes--risk of breast cancer (380 breast cancer patients and 240 normal subjects), risk

SUBMITTER: Mamtani M 

PROVIDER: S-EPMC3271971 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature