Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration.

ABSTRACT: Although astrocytes are involved in the production of an inhibitory glial scar following injury, they are also capable of providing neuroprotection and supporting axonal growth. There is growing appreciation for a diverse and dynamic population of astrocytes, specified by a variety of glial precursors, whose function is regulated regionally and temporally. Consequently, the therapeutic application of glial precursors and astrocytes by effective transplantation protocols requires a better understanding of their phenotypic and functional properties and effective protocols for their preparation. We present a systematic analysis of astrocyte differentiation using multiple preparations of glial-restricted precursors (GRP), evaluating their morphological and phenotypic properties following treat

SUBMITTER: Haas C 

PROVIDER: S-EPMC3272137 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature