Effect of surface chemistry on gene transfer efficiency mediated by surface-induced DNA-doped nanocomposites.

ABSTRACT: Surface-induced biomineralization represents an effective way of immobilizing DNA molecules on biomaterial surfaces to introduce DNA into cells in contact with or at an approximate distance from the biomaterial surfaces. Previous studies have investigated how the composition of mineralizing solutions affects the composition and pH responsiveness of nanocomposites and thus gene transfer efficiency in different cell types. This study investigates how the functional groups of a biomaterial surface affect the induction and crystallographic properties of nanocomposites and thus the gene transfer efficiency. Self-assembled monolayers with different termini were used to control the functional groups of a surface. It is demonstrated that the induction of DNA-doped nanocomposites depends on the sur

SUBMITTER: Sun B 

PROVIDER: S-EPMC3272147 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature