Molecular analysis of colorectal tumors within a diverse patient cohort at a single institution.

ABSTRACT:

Purpose

African American colorectal cancer patients have worse survival outcomes than Caucasian patients. To determine whether differences exist in the molecular mechanisms driving colorectal cancer between African Americans and Caucasians, we characterized patient tumors from a single institution by assessing genetic alterations involved in colorectal cancer progression and response to treatment.

Experimental design

We retrospectively examined 448 African Americans and Caucasians diagnosed with colorectal cancer at The University of Chicago Medical Center between 1992 and 2002. Microsatellite instability (MSI) status was determined by genotyping the BAT25, BAT26, BAT40, D5S346, and BAX loci. Mutations in KRAS codons 12 and 13 and BRAF codon 600 were identified by direct seq

SUBMITTER: Sylvester BE 

PROVIDER: S-EPMC3272273 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature