Dataset Information

Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality.

ABSTRACT:

Context

Circulating concentration of lipoprotein(a) (Lp[a]), a large glycoprotein attached to a low-density lipoprotein-like particle, may be associated with risk of coronary heart disease (CHD) and stroke.

Objective

To assess the relationship of Lp(a) concentration with risk of major vascular and nonvascular outcomes.

Study selection

Long-term prospective studies that recorded Lp(a) concentration and subsequent major vascular morbidity and/or cause-specific mortality published between January 1970 and March 2009 were identified through electronic searches of MEDLINE and other databases, manual searches of reference lists, and discussion with collaborators.