Association of RASGRP1 with type 1 diabetes is revealed by combined follow-up of two genome-wide studies.

ABSTRACT:

Background

The two genome-wide association studies published by us and by the Wellcome Trust Case-Control Consortium (WTCCC) revealed a number of novel loci, but neither had the statistical power to elucidate all of the genetic components of type 1 diabetes risk, a task for which larger effective sample sizes are needed.

Methods

We analysed data from two sources: (1) The previously published second stage of our study, with a total sample size of the two stages consisting of 1046 Canadian case-parent trios and 538 multiplex families with 929 affected offspring from the Type 1 Diabetes Genetics Consortium (T1DGC); (2) the Rapid Response 2 (RR2) project of the T1DGC, which genotyped 4417 individuals from 1062 non-overlapping families, including 2059 affected individuals (mostly

SUBMITTER: Qu HQ 

PROVIDER: S-EPMC3272492 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature