Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents.

ABSTRACT:

Background

Inflammation plays an instrumental role in all stages of atherosclerosis. High-sensitivity C-reactive protein (hsCRP), a systemic inflammatory marker, has been gaining recognition as an independent risk factor for cardiovascular disease (CVD). Both baseline hsCRP concentrations and drug-induced hsCRP changes are highly variable and potentially subject to genetic regulation.

Content

This review summarizes the current studies examining the effect of genetic and environmental factors on baseline plasma hsCRP concentrations, with a main focus on C-reactive protein, pentraxin-related (CRP) genetic polymorphisms and various dietary components that affect hsCRP concentrations. We also address the association of CRP genetic variations with CVD risk, a relationship that ma

SUBMITTER: Shen J 

PROVIDER: S-EPMC3272500 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature