Common variants in FTO are not significantly associated with obesity-related phenotypes among Samoans of Polynesia.

ABSTRACT: The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations. The limited number of studies assessing its significance in Asian populations has been somewhat conflicting. We performed a genetic association study of 51 tagging, genome-wide association studies, and imputed single nucleotide polymorphisms with 12 measures of adiposity and skeletal robustness in two Samoan populations of Polynesia. We included 465 and 624 unrelated American Samoan and Samoan individuals, respectively; these populations derive from a single genetic background traced to Southeast Asia and represent one sociocultural unit, although they are economically disparate with distinct environmental exposures. American Samoans were significantly

SUBMITTER: Karns R 

PROVIDER: S-EPMC3272784 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature