Prospective evaluation of an Australian pertussis toxin IgG and IgA enzyme immunoassay.

ABSTRACT: Serological diagnosis of recent pertussis infection is an important part of both clinical assessment and epidemiological documentation of this disease. Standardization of serological testing and interpretation remains challenging despite international efforts to improve it. Currently, determining the anti-pertussis toxin (PT) IgG titer is recommended as the most accurate serological test in Europe and the United States, while Australia relies predominantly on measurement of Bordetella pertussis IgA antibody responses. Using B. pertussis PCR and the WHO clinical case definition as reference standards, the diagnostic utility of in-house anti-PT IgG and anti-PT IgA assays was evaluated prospectively in an Australian community-based cohort (n = 327). Patients provided up to four consecutive se

SUBMITTER: May ML 

PROVIDER: S-EPMC3272923 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature