Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans.

ABSTRACT: Unlike apoptosis, necrotic cell death is characterized by marked loss of plasma membrane integrity. Leakage of cytoplasmic material to the extracellular space contributes to cell demise, and is the cause of acute inflammatory responses, which typically accompany necrosis. The mechanisms underlying plasma membrane damage during necrotic cell death are not well understood. We report that endocytosis is critically required for the execution of necrosis. Depletion of the key endocytic machinery components dynamin, synaptotagmin and endophilin suppresses necrotic neurodegeneration induced by diverse genetic and environmental insults in C. elegans. We used genetically encoded fluorescent markers to monitor the formation and fate of specific types of endosomes during cell death in vivo. Strikingl

SUBMITTER: Troulinaki K 

PROVIDER: S-EPMC3273398 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature