Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder.

ABSTRACT:

Background

A small percentage of all cases of schizophrenia have a childhood onset. The impact on the individual and family can be devastating. We report the results of genetic analyses from a patient with onset of visual hallucinations at 5 years, and a subsequent diagnosis at 9 years of schizophrenia, attention deficit hyperactivity disorder (ADHD) with hyperactivity and impulsivity, and chronic motor tic disorder.

Results

Karyotypic analysis found 45,XX,i(13)(q10) in all cells examined. Alpha satellite FISH of isochromosome 13 revealed a large unsplit centromeric region, interpreted as two centromeres separated by minimal or undetectable short-arm material or as a single monocentric centromere, indicating that the isochromosome likely formed post-zygotically by a short ar

SUBMITTER: Graw SL 

PROVIDER: S-EPMC3274485 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature