Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.

ABSTRACT:

Background

Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein-Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification.

Methods

We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided.

Results

Two novel loci associated with total cHL irrespective of EBV status were

SUBMITTER: Urayama KY 

PROVIDER: S-EPMC3274508 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature