Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

ABSTRACT:

Background

Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role in cancer cell growth and resistance to therapy. Most mutations occur at codons 12 and 13. In colorectal cancer, the presence of any mutant KRas amino acid substitution is a negative predictor of patient response to targeted therapy. However, in non-small cell lung cancer (NSCLC), the evidence that KRAS mutation is a predictive factor is conflicting.

Methods

We used data from a molecularly targeted clinical trial for 215 patients with tissues available out of 268 evaluable patients with refractory NSCLC to examine associations between specific mutant KRas proteins and progression-free survival and tumor gene expression. Transcriptome microarray studies of patient tumo

SUBMITTER: Ihle NT 

PROVIDER: S-EPMC3274509 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature