Dataset Information

Effect of CGRP and sumatriptan on the BOLD response in visual cortex.

ABSTRACT: To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 μg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after infusion and after 6 mg subcutaneous sumatriptan by functional magnetic resonance imaging (3 T). 77% of the participants reported headache after CGRP. We found no changes in brain activity after CGRP (P = 0.12) or after placebo (P = 0.41). Sumatriptan did not affect brain activity after CGRP (P = 0.71) or after placebo (P = 0.98). Systemic CGRP or sumatriptan has no direct effects on the BOLD activity in visual cortex. This suggests that in healthy volunteers both CGRP and sumatriptan may exert their actions outside of the blood-brain barrier.

SUBMITTER: Asghar MS

PROVIDER: S-EPMC3274575 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Publications

Effect of CGRP and sumatriptan on the BOLD response in visual cortex.

Asghar Mohammad S MS Hansen Adam E AE Larsson Henrik B W HB Olesen Jes J Ashina Messoud M

The journal of headache and pain 20120114 2

To test the hypothesis that calcitonin gene-related peptide (CGRP) modulates brain activity, we investigated the effect of intravenous CGRP on brain activity in response to a visual stimulus. In addition, we examined if possible alteration in brain activity was reversed by the anti-migraine drug sumatriptan. Eighteen healthy volunteers were randomly allocated to receive CGRP infusion (1.5 μg/min for 20 min) or placebo. In vivo activity in the visual cortex was recorded before, during and after i ...[more]

PMID: 22246026

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Project description:Apparent motion is a visual illusion in which stationary stimuli, flashing in distinct spatial locations at certain time intervals, are perceived as one stimulus moving between these locations. In the primary visual cortex, apparent-motion stimuli produce smooth spatio-temporal patterns of activity similar to those produced by continuously moving stimuli. An important prerequisite for producing such activity patterns is prolongation of responses to brief stimuli. Indeed, a brief stimulus can evoke in the visual cortex a long response, outlasting the stimulus by hundreds of milliseconds. Here we use firing-rate based models with simple ring structure, and biologically-detailed conductance-based refractory density (CBRD) model with retinotopic space representation to analyze the response retention and the origin of smooth profiles of activity in response to apparent-motion stimuli. We show that the strength of recurrent connectivity is the major factor that endorses neuronal networks with the ability for response retention. The same strengths of recurrent connections mediate the appearance of bump attractor in the ring models. Factors such as synaptic depression, NMDA receptor mediated currents, and conductances regulating spike adaptation influence response retention, but cannot substitute for the weakness of recurrent connections to reproduce response retention in models with weak connectivity. However, the weakness of lateral recurrent connections can be compensated by layering: in multi-layer models even with weaker connections the activity retains due to its feedforward propagation from layer to layer. Using CBRD model with retinotopic space representation we further show that smooth spatio-temporal profiles of activity in response to apparent-motion stimuli are produced in the models expressing response retention, but not in the models that fail to produce response retention. Together, these results demonstrate a link between response retention and the ability of neuronal networks to generate spatio-temporal patterns of activity, which are compatible with perception of apparent motion.

Dataset Information

Effect of CGRP and sumatriptan on the BOLD response in visual cortex.

Publications

Effect of CGRP and sumatriptan on the BOLD response in visual cortex.

Similar Datasets

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