(111)In-octreotide scintigraphy for identification of metastatic medullary thyroid carcinoma in children and adolescents.

ABSTRACT:

Context

Most medullary thyroid cancers (MTC) express somatostatin receptors; therefore, (111)In-octreotide somatostatin receptor scintigraphy (SRS) may be useful in detecting sites of metastases in children with MTC.

Objective

The aim of the study was to evaluate tumor metastases in children and adolescents with MTC using SRS in comparison to conventional imaging.

Design and setting

A case series was conducted as part of baseline evaluation for cancer treatment protocol at the National Institutes of Health Clinical Center.

Patients

Eleven patients with a median age of 15 (range, 9-17) yr participated in the study, 10 with histologically proven, metastatic MTC due to the M918T mutation of the RET protooncogene, and one with a known RET polymorphism.

Intervent

SUBMITTER: Lodish M 

PROVIDER: S-EPMC3275365 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature