ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure.

ABSTRACT:

Background

Premature ovarian failure (POF) is a complex and heterogeneous disorder that is influenced by multiple genetic components. Numerous candidate gene studies designed to identify POF susceptibility loci have been published, but most positive findings have not been confirmed in follow up studies. We sought to determine if sequence variants previously associated with age at natural menopause (AANM) or early menopause (EM) contribute as well to genetic susceptibility to POF.

Methods

Our study was performed on 371 unrelated idiopathic women with POF and 800 women controls, all Chinese Han. Thirty six SNPs from previous genome-wide association studies (GWAS) responsible for AANM or EM and 3 additional SNPs in ESR1, and 2 additional SNPs in PTHB1 were tested using the Sequ

SUBMITTER: Qin Y 

PROVIDER: S-EPMC3275465 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature