Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia.

ABSTRACT:

Background

The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors. We have recently demonstrated nominally significant associations between SAP97 gene and schizophrenia among Japanese males. The present study aimed to replicate these findings using an independent and larger sample.

Methods

We investigated seven SAP97 single nucleotide polymorphisms (SNPs) that displayed a significant association with schizophrenia in our preceding study in an independent Japanese population consisting of a total of 393 unrelated patients with schizophrenia (232 males and 161 females) and 393 unrelated contro

SUBMITTER: Uezato A 

PROVIDER: S-EPMC3275478 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature