Composite structural motifs of binding sites for delineating biological functions of proteins.

ABSTRACT: Most biological processes are described as a series of interactions between proteins and other molecules, and interactions are in turn described in terms of atomic structures. To annotate protein functions as sets of interaction states at atomic resolution, and thereby to better understand the relation between protein interactions and biological functions, we conducted exhaustive all-against-all atomic structure comparisons of all known binding sites for ligands including small molecules, proteins and nucleic acids, and identified recurring elementary motifs. By integrating the elementary motifs associated with each subunit, we defined composite motifs that represent context-dependent combinations of elementary motifs. It is demonstrated that function similarity can be better inferred from

SUBMITTER: Kinjo AR 

PROVIDER: S-EPMC3275580 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature