Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex disease.

ABSTRACT: Network models combined with gene expression studies have become useful tools for studying complex diseases like Alzheimer's disease. We constructed a "Core" Alzheimer's disease protein interaction network by human curation of the primary literature. The Core network consisted of 775 nodes and 2,204 interactions. To our knowledge, this is the most comprehensive and accurate protein interaction network yet constructed for Alzheimer's disease. An "Expanded" network was computationally constructed by adding additional proteins that interacted with Core network proteins, and consisted of 4,945 nodes and 26,064 interactions. We then mapped existing gene expression studies to the Core network. This combined data model identified the MAPK/ERK pathway and clathrin-mediated receptor endocytosis as

SUBMITTER: Hallock P 

PROVIDER: S-EPMC3275800 | biostudies-literature | 2012 Jan-Feb

REPOSITORIES: biostudies-literature