QTL Mapping and Candidate Gene Analysis of Telomere Length Control Factors in Maize (Zea mays L.).

ABSTRACT: Telomere length is a quantitative trait important for many cellular functions. Failure to regulate telomere length contributes to genomic instability, cellular senescence, cancer, and apoptosis in humans, but the functional significance of telomere regulation in plants is much less well understood. To gain a better understanding of telomere biology in plants, we used quantitative trait locus (QTL) mapping to identify genetic elements that control telomere length variation in maize (Zea mays L.). For this purpose, we measured the median and mean telomere lengths from 178 recombinant inbred lines of the IBM mapping population and found multiple regions that collectively accounted for 33-38% of the variation in telomere length. Two-way analysis of variance revealed interaction between the qua

SUBMITTER: Brown AN 

PROVIDER: S-EPMC3276162 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature