Genetic Diversity and Genomic Plasticity of Cryptococcus neoformans AD Hybrid Strains.

ABSTRACT: Natural hybridization between two strains, varieties, or species is a common phenomenon in both plants and animals. Although hybridization may skew established gene pools, it generates population diversity efficiently and sometimes results in the emergence of newly adapted genotypes. Cryptococcus neoformans, which causes the most frequent opportunistic fungal infection in immunocompromised hosts, has three serotypes: A, D, and AD. Serotype-specific multilocus sequence typing and serotype-specific comparative genome hybridization were applied to investigate the genetic variability and genomic organization of C. neoformans serotype AD isolates. We confirm that C. neoformans serotype AD isolates are hybrids of serotype A and D strains. Compared with haploid strains, most AD hybrid isolates ex

SUBMITTER: Li W 

PROVIDER: S-EPMC3276195 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature