Lagging exposure information in cumulative exposure-response analyses.

ABSTRACT: Lagging exposure information is often undertaken to allow for a latency period in cumulative exposure-disease analyses. The authors first consider bias and confidence interval coverage when using the standard approaches of fitting models under several lag assumptions and selecting the lag that maximizes either the effect estimate or model goodness of fit. Next, they consider bias that occurs when the assumption that the latency period is a fixed constant does not hold. Expressions were derived for bias due to misspecification of lag assumptions, and simulations were conducted. Finally, the authors describe a method for joint estimation of parameters describing an exposure-response association and the latency distribution. Analyses of associations between cumulative asbestos exposure and lu

SUBMITTER: Richardson DB 

PROVIDER: S-EPMC3276301 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature