Synthetic osteogenic extracellular matrix formed by coated silicon dioxide nanosprings.

ABSTRACT:

Background

The design of biomimetic materials that parallel the morphology and biology of extracellular matrixes is key to the ability to grow functional tissues in vitro and to enhance the integration of biomaterial implants into existing tissues in vivo. Special attention has been put into mimicking the nanostructures of the extracellular matrix of bone, as there is a need to find biomaterials that can enhance the bonding between orthopedic devices and this tissue.

Methods

We have tested the ability of normal human osteoblasts to propagate and differentiate on silicon dioxide nanosprings, which can be easily grown on practically any surface. In addition, we tested different metals and metal alloys as coats for the nanosprings in tissue culture experiments with bone cells.<

SUBMITTER: Hass JL 

PROVIDER: S-EPMC3276422 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature