Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population.

ABSTRACT:

Background and purpose

The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.

Methods

We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).

Results

Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LD

SUBMITTER: Predazzi IM 

PROVIDER: S-EPMC3276570 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature