Comparison of measures of marker informativeness for ancestry and admixture mapping.

ABSTRACT:

Background

Admixture mapping is a powerful gene mapping approach for an admixed population formed from ancestral populations with different allele frequencies. The power of this method relies on the ability of ancestry informative markers (AIMs) to infer ancestry along the chromosomes of admixed individuals. In this study, more than one million SNPs from HapMap databases and simulated data have been interrogated in admixed populations using various measures of ancestry informativeness: Fisher Information Content (FIC), Shannon Information Content (SIC), F statistics (FST), Informativeness for Assignment Measure (In), and the Absolute Allele Frequency Differences (delta, δ). The objectives are to compare these measures of informativeness to select SNP markers for ancestry inference,

SUBMITTER: Ding L 

PROVIDER: S-EPMC3276602 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature