Current and emerging treatment options for castration-resistant prostate cancer: a focus on immunotherapy.

ABSTRACT:

Background

Castration-resistant prostate cancer is a disease with limited treatment options. However, the ongoing elucidation of the mechanisms underlying this disease continues to support the development of not only novel agents, but also innovative approaches. Among these therapies, immunotherapy has emerged as a promising strategy.

Design

This review article summarizes the most recent data from investigations of immunotherapies in castration-resistant prostate cancer (literature and congress searches current as of August 2011).

Results

Immunotherapeutic strategies such as passive immunization, vaccines, and particularly checkpoint blockade have demonstrated some efficacy as single agents. Elucidation of effective combinations of agents and drug regimens is ongoing

SUBMITTER: Gerritsen WR 

PROVIDER: S-EPMC3276755 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature