Risk conferred by FokI polymorphism of vitamin D receptor (VDR) gene for essential hypertension.

ABSTRACT:

Background

The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to several diseases. The gene has a critical role in regulating the renin-angiotensin system (RAS) influencing the regulation of blood pressure. Hence determining the association of VDR polymorphisms with essential hypertension is expected to help in the evaluation of risk for the condition.

Aim

The aim of this study was to evaluate association between VDRFok I polymorphism and genetic susceptibility to essential hypertension.

Materials and methods

Two hundred and eighty clinically diagnosed hypertensive patients and 200 normotensive healthy controls were analyzed for Fok I (T/C) [rs2228570] polymorphism by polymerase chain reaction and restriction fragment length polymorph

SUBMITTER: Swapna N 

PROVIDER: S-EPMC3276990 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature