Effective guidance of collective migration based on differences in cell states.

ABSTRACT: Directed cell migration is important for normal animal development and physiology. The process can also be subverted by tumor cells to invade other tissues and to metastasize. Some cells, such as leukocytes, migrate individually; other cells migrate together in groups or sheets, called collective cell migration. Guidance of individually migrating cells depends critically on subcellularly localized perception and transduction of signals. For collective cell migration, guidance could result from cells within a group achieving different signaling levels, with directionality then encoded in the collective rather than in individual cells. Here we subject this collective guidance hypothesis to direct tests, using migration of border cells during Drosophila oogenesis as our model system. These ce

SUBMITTER: Inaki M 

PROVIDER: S-EPMC3277546 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature