A vector space model approach to identify genetically related diseases.

ABSTRACT:

Objective

The relationship between diseases and their causative genes can be complex, especially in the case of polygenic diseases. Further exacerbating the challenges in their study is that many genes may be causally related to multiple diseases. This study explored the relationship between diseases through the adaptation of an approach pioneered in the context of information retrieval: vector space models.

Materials and methods

A vector space model approach was developed that bridges gene disease knowledge inferred across three knowledge bases: Online Mendelian Inheritance in Man, GenBank, and Medline. The approach was then used to identify potentially related diseases for two target diseases: Alzheimer disease and Prader-Willi Syndrome.

Results

In the case of both

SUBMITTER: Sarkar IN 

PROVIDER: S-EPMC3277619 | biostudies-literature | 2012 Mar-Apr

REPOSITORIES: biostudies-literature