Circulating angiogenic cell populations, vascular function, and arterial stiffness.

ABSTRACT:

Objective

Several bone marrow-derived cell populations have been identified that may possess angiogenic activity and contribute to vascular homeostasis in experimental studies. We examined the extent to which lower quantities of these circulating angiogenic cell phenotypes may be related to impaired vascular function and greater arterial stiffness.

Methods

We studied 1948 Framingham Heart Study participants (mean age, 66±9 years; 54% women) who were phenotyped for circulating angiogenic cells: CD34+, CD34+/KDR+, and early outgrowth colony forming units (CFU). Participants underwent non-invasive assessments of vascular function including peripheral arterial tone (PAT), arterial tonometry, and brachial reactivity testing.

Results

In unadjusted analyses, higher CD34+ and

SUBMITTER: Cheng S 

PROVIDER: S-EPMC3277804 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature