Identification of cytokines and signaling proteins differentially regulated by sumatriptan/naproxen.

ABSTRACT:

Objectives

The goal of this study was to use protein array analysis to investigate temporal regulation of stimulated cytokine expression in trigeminal ganglia and the spinal trigeminal nucleus in response to co-treatment of sumatriptan and naproxen sodium or individual drug.

Background

Activation of neurons and glia in trigeminal ganglia and the spinal trigeminal nucleus leads to increased levels of cytokines that promote peripheral and central sensitization, which are key events in migraine pathology. While recent clinical studies have provided evidence that a combination of sumatriptan and naproxen sodium is more efficacious in treating migraine than either drug alone, it is not well understood why the combination therapy is superior to monotherapy.

Methods

Male Spr

SUBMITTER: Vause CV 

PROVIDER: S-EPMC3277868 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature