Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.

ABSTRACT:

Aim

Individuals differ in their inherited tendency to develop cancer. This has been suggested to be due to genetic variations between individuals. Single-nucleotide polymorphisms (SNPs) are the most common form of genetic variations found in the human population. The aim of this study was to investigate the association between 10 SNPs in genes involved in cell cycle control and DNA repair (p21 C31A, p53 G72C, ATM G1853A, XRCC1 G399A, XRCC3 C241T, Ku80 A2790G, DNA Ligase IV C9T, DNA-PKcs A3434G, TGF-beta T10C, MDM2 promoter T309G) and the risk to develop head and neck cancer.

Materials and methods

A cohort of 407 individuals (156 cancer patients and 251 controls) was included. DNA was extracted from peripheral blood. SNPs were genotyped by direct sequencing.

Results

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SUBMITTER: Al-Hadyan KS 

PROVIDER: S-EPMC3277923 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature