Habitual dietary sodium intake is inversely associated with coronary flow reserve in middle-aged male twins.

ABSTRACT:

Background

Evidence links dietary sodium to hypertension and cardiovascular disease (CVD), but investigation of its influence on cardiovascular function is limited.

Objective

We examined the relation between habitual dietary sodium and coronary flow reserve (CFR), which is a measure of overall coronary vasodilator capacity and microvascular function. We hypothesized that increased sodium consumption is associated with lower CFR.

Design

Habitual daily sodium intake for the previous 12 mo was measured in 286 male middle-aged twins (133 monozygotic and dizygotic pairs and 20 unpaired twins) by using the Willett food-frequency questionnaire. CFR was measured by positron emission tomography [N(13)]-ammonia, with quantitation of myocardial blood flow at rest and after adeno

SUBMITTER: Eufinger SC 

PROVIDER: S-EPMC3278238 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature