Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trial.

ABSTRACT:

Background

Weight loss reduces body fat and lean mass, but whether these changes are influenced by macronutrient composition of the diet is unclear.

Objective

We determined whether energy-reduced diets that emphasize fat, protein, or carbohydrate differentially reduce total, visceral, or hepatic fat or preserve lean mass.

Design

In a subset of participants in a randomized trial of 4 weight-loss diets, body fat and lean mass (n = 424; by using dual-energy X-ray absorptiometry) and abdominal and hepatic fat (n = 165; by using computed tomography) were measured after 6 mo and 2 y. Changes from baseline were compared between assigned amounts of protein (25% compared with 15%) and fat (40% compared with 20%) and across 4 carbohydrate amounts (35% through 65%).

Results</

SUBMITTER: de Souza RJ 

PROVIDER: S-EPMC3278241 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature